Glycated Hemoglobin Measurement and Prediction of Cardiovascular Disease
Identifieur interne : 004139 ( Main/Exploration ); précédent : 004138; suivant : 004140Glycated Hemoglobin Measurement and Prediction of Cardiovascular Disease
Auteurs : Emanuele Di Angelantonio [Royaume-Uni] ; Pei Gao [Royaume-Uni] ; Hassan Khan [Royaume-Uni] ; Adam S. Butterworth [Royaume-Uni] ; David Wormser [Royaume-Uni] ; Stephen Kaptoge [Royaume-Uni] ; SREENIVASA RAO KONDAPALLY SESHASAI [Royaume-Uni] ; Alex Thompson [Royaume-Uni] ; Nadeem Sarwar [Royaume-Uni] ; Peter Willeit [Royaume-Uni] ; Paul M. Ridker [États-Unis] ; Elizabeth L. M. Barr [Australie] ; Kay-Tee Khaw [Royaume-Uni] ; Bruce M. Psaty [États-Unis] ; Hermann Brenner [Allemagne] ; Beverley Balkau [France] ; Jacqueline M. Dekker [Pays-Bas] ; Debbie A. Lawlor [Royaume-Uni] ; Makoto Daimon [Japon] ; Johann Willeit [Autriche] ; Inger Nj Lstad [Norvège] ; Aulikki Nissinen [Finlande] ; Eric J. Brunner [Royaume-Uni] ; Lewis H. Kuller [États-Unis] ; Jackie F. Price [Royaume-Uni] ; Johan Sundström [Suède] ; Matthew W. Knuiman [Australie] ; Edith J. M. Feskens [Pays-Bas] ; W. M. M. Verschuren [Pays-Bas] ; Nicholas Wald [Royaume-Uni] ; Stephan J. L. Bakker [Pays-Bas] ; Peter H. Whincup [Royaume-Uni] ; Ian Ford ; Uri Goldbourt ; Agustin Gomez-De-Ia-Camara ; John Gallacher ; Leon A. Simons ; Annika Rosengren ; Susan E. Sutherland ; Cecilia Björkelund ; Dan G. Blazer ; Sylvia Wassertheil-Smoller ; Altan Onat ; Alejandro Marín Ibanez ; Edoardo Casiglia ; J. Wouter Jukema ; Lara M. Simpson ; Simona Giampaoli ; Barge G. Nordestgaard ; Randi Selmer ; Patrik Wennberg ; Jussi Kauhanen ; Jukka T. Salonen ; Rachel Dankner ; Elizabeth Barrett-Connor ; Maryam Kavousi ; Vilmundur Gudnason ; Denis Evans ; Robert B. Wallace ; Mary CushmanSource :
- JAMA, the journal of the American Medical Association [ 0098-7484 ] ; 2014.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Analyse quantitative, Médecine.
English descriptors
- KwdEn :
Abstract
IMPORTANCE The value of measuring levels of glycated hemoglobin (HbA1c) for the prediction of first cardiovascular events is uncertain. OBJECTIVE To determine whether adding information on HbA1c values to conventional cardiovascular risk factors is associated with improvement in prediction of cardiovascular disease (CVD) risk. DESIGN. SETTING, AND PARTICIPANTS Analysis of individual-participant data available from 73 prospective studies involving 294 998 participants without a known history of diabetes mellitus or CVD at the baseline assessment. MAIN OUTCOMES AND MEASURES Measures of risk discrimination for CVD outcomes (eg, C-index) and reclassification (eg, net reclassification improvement) of participants across predicted 10-year risk categories of low (<5%), intermediate (5% to <7.5%), and high (≥7.5%) risk. RESULTS During a median follow-up of 9.9 (interquartile range, 7.6-13.2) years, 20 840 incident fatal and nonfatal CVD outcomes (13 237 coronary heart disease and 7603 stroke outcomes) were recorded. In analyses adjusted for several conventional cardiovascular risk factors, there was an approximately J-shaped association between HbA1c values and CVD risk. The association between HbA1c values and CVD risk changed only slightly after adjustment for total cholesterol and triglyceride concentrations or estimated glomerular filtration rate, but this association attenuated somewhat after adjustment for concentrations of high-density lipoprotein cholesterol and C-reactive protein. The C-index for a CVD risk prediction model containing conventional cardiovascular risk factors alone was 0.7434 (95% CI, 0.7350 to 0.7517). The addition of information on HbA1c was associated with a C-index change of 0.0018 (0.0003 to 0.0033) and a net reclassification improvement of 0.42 (-0.63 to 1.48) for the categories of predicted 10-year CVD risk. The improvement provided by HbA1c assessment in prediction of CVD risk was equal to or better than estimated improvements for measurement of fasting, random, or postload plasma glucose levels. CONCLUSIONS AND RELEVANCE In a study of individuals without known CVD or diabetes, additional assessment of HbA1c values in the context of CVD risk assessment provided little incremental benefit for prediction of CVD risk.
Affiliations:
- Allemagne, Australie, Autriche, Finlande, France, Japon, Norvège, Pays-Bas, Royaume-Uni, Suède, États-Unis
- Angleterre, Angleterre de l'Est, Bade-Wurtemberg, District de Karlsruhe, East Middle Sweden, Grand Londres, Groningue (province), Gueldre (province), Hollande-Septentrionale, Massachusetts, Pennsylvanie, Svealand, Washington (État), Écosse
- Amsterdam, Cambridge, Groningue (ville), Heidelberg, Londres, Pittsburgh, Seattle, Uppsala, Wageningue, Édimbourg
- University College de Londres, Université d'Uppsala, Université d'Édimbourg, Université de Cambridge, Université de Groningue, Université de Londres, Université de Pittsburgh, Université de Wageningue, Université de Washington
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Psaty</name><affiliation wicri:level="4"><inist:fA14 i1="05"><s1>University of Washington</s1><s2>Seattle</s2><s3>USA</s3><sZ>14 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Seattle</settlement><region type="state">Washington (État)</region></placeName><orgName type="university">Université de Washington</orgName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="06"><s1>Group Health Research Institute</s1><s2>Seattle, Washington</s2><s3>USA</s3><sZ>14 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><affiliation wicri:level="3"><inist:fA14 i1="07"><s1>German Cancer Research Center</s1><s2>Heidelberg</s2><s3>DEU</s3><sZ>15 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Balkau, Beverley" sort="Balkau, Beverley" uniqKey="Balkau B" first="Beverley" last="Balkau">Beverley Balkau</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Inserm</s1><s2>Villejuif</s2><s3>FRA</s3><sZ>16 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Inserm</wicri:noRegion><wicri:noRegion>Inserm</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>University Paris-Sud</s1><s2>Villejuif</s2><s3>FRA</s3><sZ>16 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>University Paris-Sud</wicri:noRegion><wicri:noRegion>University Paris-Sud</wicri:noRegion></affiliation></author><author><name sortKey="Dekker, Jacqueline M" sort="Dekker, Jacqueline M" uniqKey="Dekker J" first="Jacqueline M." last="Dekker">Jacqueline M. Dekker</name><affiliation wicri:level="3"><inist:fA14 i1="10"><s1>Vrije Universiteit Medical Center</s1><s2>Amsterdam</s2><s3>NLD</s3><sZ>17 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Lawlor, Debbie A" sort="Lawlor, Debbie A" uniqKey="Lawlor D" first="Debbie A." last="Lawlor">Debbie A. Lawlor</name><affiliation wicri:level="1"><inist:fA14 i1="11"><s1>University of Bristol</s1><s2>Bristol</s2><s3>GBR</s3><sZ>18 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>University of Bristol</wicri:noRegion></affiliation></author><author><name sortKey="Daimon, Makoto" sort="Daimon, Makoto" uniqKey="Daimon M" first="Makoto" last="Daimon">Makoto Daimon</name><affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Yamagata University</s1><s3>JPN</s3><sZ>19 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Yamagata University</wicri:noRegion></affiliation></author><author><name sortKey="Willeit, Johann" sort="Willeit, Johann" uniqKey="Willeit J" first="Johann" last="Willeit">Johann Willeit</name><affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Medical University Innsbruck</s1><s3>AUT</s3><sZ>20 aut.</sZ></inist:fA14><country>Autriche</country><wicri:noRegion>Medical University Innsbruck</wicri:noRegion></affiliation></author><author><name sortKey="Nj Lstad, Inger" sort="Nj Lstad, Inger" uniqKey="Nj Lstad I" first="Inger" last="Nj Lstad">Inger Nj Lstad</name><affiliation wicri:level="1"><inist:fA14 i1="14"><s1>University of Tromsø</s1><s2>Tromsø</s2><s3>NOR</s3><sZ>21 aut.</sZ></inist:fA14><country>Norvège</country><wicri:noRegion>University of Tromsø</wicri:noRegion></affiliation></author><author><name sortKey="Nissinen, Aulikki" sort="Nissinen, Aulikki" uniqKey="Nissinen A" first="Aulikki" last="Nissinen">Aulikki Nissinen</name><affiliation wicri:level="1"><inist:fA14 i1="15"><s1>National Institute of Health and Welfare</s1><s2>Helsinki</s2><s3>FIN</s3><sZ>22 aut.</sZ></inist:fA14><country>Finlande</country><wicri:noRegion>National Institute of Health and Welfare</wicri:noRegion></affiliation></author><author><name sortKey="Brunner, Eric J" sort="Brunner, Eric J" uniqKey="Brunner E" first="Eric J." last="Brunner">Eric J. Brunner</name><affiliation wicri:level="4"><inist:fA14 i1="16"><s1>University College London</s1><s2>London</s2><s3>GBR</s3><sZ>23 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Kuller, Lewis H" sort="Kuller, Lewis H" uniqKey="Kuller L" first="Lewis H." last="Kuller">Lewis H. Kuller</name><affiliation wicri:level="4"><inist:fA14 i1="17"><s1>University of Pittsburgh</s1><s3>USA</s3><sZ>24 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Price, Jackie F" sort="Price, Jackie F" uniqKey="Price J" first="Jackie F." last="Price">Jackie F. Price</name><affiliation wicri:level="4"><inist:fA14 i1="18"><s1>University of Edinburgh</s1><s2>Edinburgh</s2><s3>GBR</s3><sZ>25 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region><settlement type="city">Édimbourg</settlement></placeName><orgName type="university">Université d'Édimbourg</orgName></affiliation></author><author><name sortKey="Sundstrom, Johan" sort="Sundstrom, Johan" uniqKey="Sundstrom J" first="Johan" last="Sundström">Johan Sundström</name><affiliation wicri:level="4"><inist:fA14 i1="19"><s1>Uppsala University</s1><s2>Uppsala</s2><s3>SWE</s3><sZ>26 aut.</sZ></inist:fA14><country>Suède</country><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName><orgName type="university">Université d'Uppsala</orgName></affiliation></author><author><name sortKey="Knuiman, Matthew W" sort="Knuiman, Matthew W" uniqKey="Knuiman M" first="Matthew W." last="Knuiman">Matthew W. Knuiman</name><affiliation wicri:level="1"><inist:fA14 i1="20"><s1>University of Western Australia</s1><s2>Perth</s2><s3>AUS</s3><sZ>27 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>University of Western Australia</wicri:noRegion></affiliation></author><author><name sortKey="Feskens, Edith J M" sort="Feskens, Edith J M" uniqKey="Feskens E" first="Edith J. M." last="Feskens">Edith J. M. Feskens</name><affiliation wicri:level="4"><inist:fA14 i1="21"><s1>Wageningen University</s1><s2>Wageningen</s2><s3>NLD</s3><sZ>28 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Wageningue</settlement><region nuts="2">Gueldre (province)</region></placeName><orgName type="university">Université de Wageningue</orgName></affiliation></author><author><name sortKey="Verschuren, W M M" sort="Verschuren, W M M" uniqKey="Verschuren W" first="W. M. M." last="Verschuren">W. M. M. Verschuren</name><affiliation wicri:level="1"><inist:fA14 i1="22"><s1>National Institute for Public Health and the Environment (RIVM)</s1><s2>Bilthoven</s2><s3>NLD</s3><sZ>29 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>National Institute for Public Health and the Environment (RIVM)</wicri:noRegion></affiliation></author><author><name sortKey="Wald, Nicholas" sort="Wald, Nicholas" uniqKey="Wald N" first="Nicholas" last="Wald">Nicholas Wald</name><affiliation wicri:level="3"><inist:fA14 i1="23"><s1>Wolfson Institute of Preventive Medicine</s1><s2>London</s2><s3>GBR</s3><sZ>30 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Bakker, Stephan J L" sort="Bakker, Stephan J L" uniqKey="Bakker S" first="Stephan J. L." last="Bakker">Stephan J. L. Bakker</name><affiliation wicri:level="4"><inist:fA14 i1="24"><s1>University of Groningen, University Medical Center Groningen</s1><s3>NLD</s3><sZ>31 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>University of Groningen, University Medical Center Groningen</wicri:noRegion><orgName type="university">Université de Groningue</orgName><placeName><settlement type="city">Groningue (ville)</settlement><region>Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Whincup, Peter H" sort="Whincup, Peter H" uniqKey="Whincup P" first="Peter H." last="Whincup">Peter H. Whincup</name><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>St George's University of London</s1><s2>London</s2><s3>GBR</s3><sZ>7 aut.</sZ><sZ>32 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">Université de Londres</orgName></affiliation></author><author><name sortKey="Ford, Ian" sort="Ford, Ian" uniqKey="Ford I" first="Ian" last="Ford">Ian Ford</name></author><author><name sortKey="Goldbourt, Uri" sort="Goldbourt, Uri" uniqKey="Goldbourt U" first="Uri" last="Goldbourt">Uri Goldbourt</name></author><author><name sortKey="Gomez De Ia Camara, Agustin" sort="Gomez De Ia Camara, Agustin" uniqKey="Gomez De Ia Camara A" first="Agustin" last="Gomez-De-Ia-Camara">Agustin Gomez-De-Ia-Camara</name></author><author><name sortKey="Gallacher, John" sort="Gallacher, John" uniqKey="Gallacher J" first="John" last="Gallacher">John Gallacher</name></author><author><name sortKey="Simons, Leon A" sort="Simons, Leon A" uniqKey="Simons L" first="Leon A." last="Simons">Leon A. Simons</name></author><author><name sortKey="Rosengren, Annika" sort="Rosengren, Annika" uniqKey="Rosengren A" first="Annika" last="Rosengren">Annika Rosengren</name></author><author><name sortKey="Sutherland, Susan E" sort="Sutherland, Susan E" uniqKey="Sutherland S" first="Susan E." last="Sutherland">Susan E. Sutherland</name></author><author><name sortKey="Bjorkelund, Cecilia" sort="Bjorkelund, Cecilia" uniqKey="Bjorkelund C" first="Cecilia" last="Björkelund">Cecilia Björkelund</name></author><author><name sortKey="Blazer, Dan G" sort="Blazer, Dan G" uniqKey="Blazer D" first="Dan G." last="Blazer">Dan G. Blazer</name></author><author><name sortKey="Wassertheil Smoller, Sylvia" sort="Wassertheil Smoller, Sylvia" uniqKey="Wassertheil Smoller S" first="Sylvia" last="Wassertheil-Smoller">Sylvia Wassertheil-Smoller</name></author><author><name sortKey="Onat, Altan" sort="Onat, Altan" uniqKey="Onat A" first="Altan" last="Onat">Altan Onat</name></author><author><name sortKey="Ibanez, Alejandro Marin" sort="Ibanez, Alejandro Marin" uniqKey="Ibanez A" first="Alejandro Marín" last="Ibanez">Alejandro Marín Ibanez</name></author><author><name sortKey="Casiglia, Edoardo" sort="Casiglia, Edoardo" uniqKey="Casiglia E" first="Edoardo" last="Casiglia">Edoardo Casiglia</name></author><author><name sortKey="Jukema, J Wouter" sort="Jukema, J Wouter" uniqKey="Jukema J" first="J. Wouter" last="Jukema">J. Wouter Jukema</name></author><author><name sortKey="Simpson, Lara M" sort="Simpson, Lara M" uniqKey="Simpson L" first="Lara M." last="Simpson">Lara M. Simpson</name></author><author><name sortKey="Giampaoli, Simona" sort="Giampaoli, Simona" uniqKey="Giampaoli S" first="Simona" last="Giampaoli">Simona Giampaoli</name></author><author><name sortKey="Nordestgaard, Barge G" sort="Nordestgaard, Barge G" uniqKey="Nordestgaard B" first="Barge G." last="Nordestgaard">Barge G. Nordestgaard</name></author><author><name sortKey="Selmer, Randi" sort="Selmer, Randi" uniqKey="Selmer R" first="Randi" last="Selmer">Randi Selmer</name></author><author><name sortKey="Wennberg, Patrik" sort="Wennberg, Patrik" uniqKey="Wennberg P" first="Patrik" last="Wennberg">Patrik Wennberg</name></author><author><name sortKey="Kauhanen, Jussi" sort="Kauhanen, Jussi" uniqKey="Kauhanen J" first="Jussi" last="Kauhanen">Jussi Kauhanen</name></author><author><name sortKey="Salonen, Jukka T" sort="Salonen, Jukka T" uniqKey="Salonen J" first="Jukka T." last="Salonen">Jukka T. Salonen</name></author><author><name sortKey="Dankner, Rachel" sort="Dankner, Rachel" uniqKey="Dankner R" first="Rachel" last="Dankner">Rachel Dankner</name></author><author><name sortKey="Barrett Connor, Elizabeth" sort="Barrett Connor, Elizabeth" uniqKey="Barrett Connor E" first="Elizabeth" last="Barrett-Connor">Elizabeth Barrett-Connor</name></author><author><name sortKey="Kavousi, Maryam" sort="Kavousi, Maryam" uniqKey="Kavousi M" first="Maryam" last="Kavousi">Maryam Kavousi</name></author><author><name sortKey="Gudnason, Vilmundur" sort="Gudnason, Vilmundur" uniqKey="Gudnason V" first="Vilmundur" last="Gudnason">Vilmundur Gudnason</name></author><author><name sortKey="Evans, Denis" sort="Evans, Denis" uniqKey="Evans D" first="Denis" last="Evans">Denis Evans</name></author><author><name sortKey="Wallace, Robert B" sort="Wallace, Robert B" uniqKey="Wallace R" first="Robert B." last="Wallace">Robert B. Wallace</name></author><author><name sortKey="Cushman, Mary" sort="Cushman, Mary" uniqKey="Cushman M" first="Mary" last="Cushman">Mary Cushman</name></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">14-0094675</idno><date when="2014">2014</date><idno type="stanalyst">PASCAL 14-0094675 INIST</idno><idno type="RBID">Pascal:14-0094675</idno><idno type="wicri:Area/PascalFrancis/Corpus">000496</idno><idno type="wicri:Area/PascalFrancis/Curation">005965</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000278</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000278</idno><idno type="wicri:doubleKey">0098-7484:2014:Di Angelantonio E:glycated:hemoglobin:measurement</idno><idno type="wicri:Area/Main/Merge">004202</idno><idno type="wicri:Area/Main/Curation">004139</idno><idno type="wicri:Area/Main/Exploration">004139</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Glycated Hemoglobin Measurement and Prediction of Cardiovascular Disease</title><author><name sortKey="Di Angelantonio, Emanuele" sort="Di Angelantonio, Emanuele" uniqKey="Di Angelantonio E" first="Emanuele" last="Di Angelantonio">Emanuele Di Angelantonio</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>University of Cambridge</s1><s2>Cambridge</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation></author><author><name sortKey="Gao, Pei" sort="Gao, Pei" uniqKey="Gao P" first="Pei" last="Gao">Pei Gao</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>University of Cambridge</s1><s2>Cambridge</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation></author><author><name sortKey="Khan, Hassan" sort="Khan, Hassan" uniqKey="Khan H" first="Hassan" last="Khan">Hassan Khan</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>University of Cambridge</s1><s2>Cambridge</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation></author><author><name sortKey="Butterworth, Adam S" sort="Butterworth, Adam S" uniqKey="Butterworth A" first="Adam S." last="Butterworth">Adam S. Butterworth</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>University of Cambridge</s1><s2>Cambridge</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation></author><author><name sortKey="Wormser, David" sort="Wormser, David" uniqKey="Wormser D" first="David" last="Wormser">David Wormser</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>University of Cambridge</s1><s2>Cambridge</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation></author><author><name sortKey="Kaptoge, Stephen" sort="Kaptoge, Stephen" uniqKey="Kaptoge S" first="Stephen" last="Kaptoge">Stephen Kaptoge</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>University of Cambridge</s1><s2>Cambridge</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation></author><author><name sortKey="Sreenivasa Rao Kondapally Seshasai" sort="Sreenivasa Rao Kondapally Seshasai" uniqKey="Sreenivasa Rao Kondapally Seshasai" last="Sreenivasa Rao Kondapally Seshasai">SREENIVASA RAO KONDAPALLY SESHASAI</name><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>St George's University of London</s1><s2>London</s2><s3>GBR</s3><sZ>7 aut.</sZ><sZ>32 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">Université de Londres</orgName></affiliation></author><author><name sortKey="Thompson, Alex" sort="Thompson, Alex" uniqKey="Thompson A" first="Alex" last="Thompson">Alex Thompson</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>University of Cambridge</s1><s2>Cambridge</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation></author><author><name sortKey="Sarwar, Nadeem" sort="Sarwar, Nadeem" uniqKey="Sarwar N" first="Nadeem" last="Sarwar">Nadeem Sarwar</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>University of Cambridge</s1><s2>Cambridge</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation></author><author><name sortKey="Willeit, Peter" sort="Willeit, Peter" uniqKey="Willeit P" first="Peter" last="Willeit">Peter Willeit</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>University of Cambridge</s1><s2>Cambridge</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation></author><author><name sortKey="Ridker, Paul M" sort="Ridker, Paul M" uniqKey="Ridker P" first="Paul M." last="Ridker">Paul M. Ridker</name><affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Brigham and Women's Hospital</s1><s2>Boston, Massachusetts</s2><s3>USA</s3><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Barr, Elizabeth L M" sort="Barr, Elizabeth L M" uniqKey="Barr E" first="Elizabeth L. M." last="Barr">Elizabeth L. M. Barr</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Baker IDI Heart and Diabetes Institute</s1><s2>Victoria</s2><s3>AUS</s3><sZ>12 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Baker IDI Heart and Diabetes Institute</wicri:noRegion></affiliation></author><author><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay-Tee" last="Khaw">Kay-Tee Khaw</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>University of Cambridge</s1><s2>Cambridge</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation></author><author><name sortKey="Psaty, Bruce M" sort="Psaty, Bruce M" uniqKey="Psaty B" first="Bruce M." last="Psaty">Bruce M. Psaty</name><affiliation wicri:level="4"><inist:fA14 i1="05"><s1>University of Washington</s1><s2>Seattle</s2><s3>USA</s3><sZ>14 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Seattle</settlement><region type="state">Washington (État)</region></placeName><orgName type="university">Université de Washington</orgName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="06"><s1>Group Health Research Institute</s1><s2>Seattle, Washington</s2><s3>USA</s3><sZ>14 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><affiliation wicri:level="3"><inist:fA14 i1="07"><s1>German Cancer Research Center</s1><s2>Heidelberg</s2><s3>DEU</s3><sZ>15 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Balkau, Beverley" sort="Balkau, Beverley" uniqKey="Balkau B" first="Beverley" last="Balkau">Beverley Balkau</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Inserm</s1><s2>Villejuif</s2><s3>FRA</s3><sZ>16 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Inserm</wicri:noRegion><wicri:noRegion>Inserm</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>University Paris-Sud</s1><s2>Villejuif</s2><s3>FRA</s3><sZ>16 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>University Paris-Sud</wicri:noRegion><wicri:noRegion>University Paris-Sud</wicri:noRegion></affiliation></author><author><name sortKey="Dekker, Jacqueline M" sort="Dekker, Jacqueline M" uniqKey="Dekker J" first="Jacqueline M." last="Dekker">Jacqueline M. Dekker</name><affiliation wicri:level="3"><inist:fA14 i1="10"><s1>Vrije Universiteit Medical Center</s1><s2>Amsterdam</s2><s3>NLD</s3><sZ>17 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Lawlor, Debbie A" sort="Lawlor, Debbie A" uniqKey="Lawlor D" first="Debbie A." last="Lawlor">Debbie A. Lawlor</name><affiliation wicri:level="1"><inist:fA14 i1="11"><s1>University of Bristol</s1><s2>Bristol</s2><s3>GBR</s3><sZ>18 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>University of Bristol</wicri:noRegion></affiliation></author><author><name sortKey="Daimon, Makoto" sort="Daimon, Makoto" uniqKey="Daimon M" first="Makoto" last="Daimon">Makoto Daimon</name><affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Yamagata University</s1><s3>JPN</s3><sZ>19 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Yamagata University</wicri:noRegion></affiliation></author><author><name sortKey="Willeit, Johann" sort="Willeit, Johann" uniqKey="Willeit J" first="Johann" last="Willeit">Johann Willeit</name><affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Medical University Innsbruck</s1><s3>AUT</s3><sZ>20 aut.</sZ></inist:fA14><country>Autriche</country><wicri:noRegion>Medical University Innsbruck</wicri:noRegion></affiliation></author><author><name sortKey="Nj Lstad, Inger" sort="Nj Lstad, Inger" uniqKey="Nj Lstad I" first="Inger" last="Nj Lstad">Inger Nj Lstad</name><affiliation wicri:level="1"><inist:fA14 i1="14"><s1>University of Tromsø</s1><s2>Tromsø</s2><s3>NOR</s3><sZ>21 aut.</sZ></inist:fA14><country>Norvège</country><wicri:noRegion>University of Tromsø</wicri:noRegion></affiliation></author><author><name sortKey="Nissinen, Aulikki" sort="Nissinen, Aulikki" uniqKey="Nissinen A" first="Aulikki" last="Nissinen">Aulikki Nissinen</name><affiliation wicri:level="1"><inist:fA14 i1="15"><s1>National Institute of Health and Welfare</s1><s2>Helsinki</s2><s3>FIN</s3><sZ>22 aut.</sZ></inist:fA14><country>Finlande</country><wicri:noRegion>National Institute of Health and Welfare</wicri:noRegion></affiliation></author><author><name sortKey="Brunner, Eric J" sort="Brunner, Eric J" uniqKey="Brunner E" first="Eric J." last="Brunner">Eric J. Brunner</name><affiliation wicri:level="4"><inist:fA14 i1="16"><s1>University College London</s1><s2>London</s2><s3>GBR</s3><sZ>23 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Kuller, Lewis H" sort="Kuller, Lewis H" uniqKey="Kuller L" first="Lewis H." last="Kuller">Lewis H. Kuller</name><affiliation wicri:level="4"><inist:fA14 i1="17"><s1>University of Pittsburgh</s1><s3>USA</s3><sZ>24 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Price, Jackie F" sort="Price, Jackie F" uniqKey="Price J" first="Jackie F." last="Price">Jackie F. Price</name><affiliation wicri:level="4"><inist:fA14 i1="18"><s1>University of Edinburgh</s1><s2>Edinburgh</s2><s3>GBR</s3><sZ>25 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region><settlement type="city">Édimbourg</settlement></placeName><orgName type="university">Université d'Édimbourg</orgName></affiliation></author><author><name sortKey="Sundstrom, Johan" sort="Sundstrom, Johan" uniqKey="Sundstrom J" first="Johan" last="Sundström">Johan Sundström</name><affiliation wicri:level="4"><inist:fA14 i1="19"><s1>Uppsala University</s1><s2>Uppsala</s2><s3>SWE</s3><sZ>26 aut.</sZ></inist:fA14><country>Suède</country><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName><orgName type="university">Université d'Uppsala</orgName></affiliation></author><author><name sortKey="Knuiman, Matthew W" sort="Knuiman, Matthew W" uniqKey="Knuiman M" first="Matthew W." last="Knuiman">Matthew W. Knuiman</name><affiliation wicri:level="1"><inist:fA14 i1="20"><s1>University of Western Australia</s1><s2>Perth</s2><s3>AUS</s3><sZ>27 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>University of Western Australia</wicri:noRegion></affiliation></author><author><name sortKey="Feskens, Edith J M" sort="Feskens, Edith J M" uniqKey="Feskens E" first="Edith J. M." last="Feskens">Edith J. M. Feskens</name><affiliation wicri:level="4"><inist:fA14 i1="21"><s1>Wageningen University</s1><s2>Wageningen</s2><s3>NLD</s3><sZ>28 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Wageningue</settlement><region nuts="2">Gueldre (province)</region></placeName><orgName type="university">Université de Wageningue</orgName></affiliation></author><author><name sortKey="Verschuren, W M M" sort="Verschuren, W M M" uniqKey="Verschuren W" first="W. M. M." last="Verschuren">W. M. M. Verschuren</name><affiliation wicri:level="1"><inist:fA14 i1="22"><s1>National Institute for Public Health and the Environment (RIVM)</s1><s2>Bilthoven</s2><s3>NLD</s3><sZ>29 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>National Institute for Public Health and the Environment (RIVM)</wicri:noRegion></affiliation></author><author><name sortKey="Wald, Nicholas" sort="Wald, Nicholas" uniqKey="Wald N" first="Nicholas" last="Wald">Nicholas Wald</name><affiliation wicri:level="3"><inist:fA14 i1="23"><s1>Wolfson Institute of Preventive Medicine</s1><s2>London</s2><s3>GBR</s3><sZ>30 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Bakker, Stephan J L" sort="Bakker, Stephan J L" uniqKey="Bakker S" first="Stephan J. L." last="Bakker">Stephan J. L. Bakker</name><affiliation wicri:level="4"><inist:fA14 i1="24"><s1>University of Groningen, University Medical Center Groningen</s1><s3>NLD</s3><sZ>31 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>University of Groningen, University Medical Center Groningen</wicri:noRegion><orgName type="university">Université de Groningue</orgName><placeName><settlement type="city">Groningue (ville)</settlement><region>Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Whincup, Peter H" sort="Whincup, Peter H" uniqKey="Whincup P" first="Peter H." last="Whincup">Peter H. Whincup</name><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>St George's University of London</s1><s2>London</s2><s3>GBR</s3><sZ>7 aut.</sZ><sZ>32 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">Université de Londres</orgName></affiliation></author><author><name sortKey="Ford, Ian" sort="Ford, Ian" uniqKey="Ford I" first="Ian" last="Ford">Ian Ford</name></author><author><name sortKey="Goldbourt, Uri" sort="Goldbourt, Uri" uniqKey="Goldbourt U" first="Uri" last="Goldbourt">Uri Goldbourt</name></author><author><name sortKey="Gomez De Ia Camara, Agustin" sort="Gomez De Ia Camara, Agustin" uniqKey="Gomez De Ia Camara A" first="Agustin" last="Gomez-De-Ia-Camara">Agustin Gomez-De-Ia-Camara</name></author><author><name sortKey="Gallacher, John" sort="Gallacher, John" uniqKey="Gallacher J" first="John" last="Gallacher">John Gallacher</name></author><author><name sortKey="Simons, Leon A" sort="Simons, Leon A" uniqKey="Simons L" first="Leon A." last="Simons">Leon A. Simons</name></author><author><name sortKey="Rosengren, Annika" sort="Rosengren, Annika" uniqKey="Rosengren A" first="Annika" last="Rosengren">Annika Rosengren</name></author><author><name sortKey="Sutherland, Susan E" sort="Sutherland, Susan E" uniqKey="Sutherland S" first="Susan E." last="Sutherland">Susan E. Sutherland</name></author><author><name sortKey="Bjorkelund, Cecilia" sort="Bjorkelund, Cecilia" uniqKey="Bjorkelund C" first="Cecilia" last="Björkelund">Cecilia Björkelund</name></author><author><name sortKey="Blazer, Dan G" sort="Blazer, Dan G" uniqKey="Blazer D" first="Dan G." last="Blazer">Dan G. Blazer</name></author><author><name sortKey="Wassertheil Smoller, Sylvia" sort="Wassertheil Smoller, Sylvia" uniqKey="Wassertheil Smoller S" first="Sylvia" last="Wassertheil-Smoller">Sylvia Wassertheil-Smoller</name></author><author><name sortKey="Onat, Altan" sort="Onat, Altan" uniqKey="Onat A" first="Altan" last="Onat">Altan Onat</name></author><author><name sortKey="Ibanez, Alejandro Marin" sort="Ibanez, Alejandro Marin" uniqKey="Ibanez A" first="Alejandro Marín" last="Ibanez">Alejandro Marín Ibanez</name></author><author><name sortKey="Casiglia, Edoardo" sort="Casiglia, Edoardo" uniqKey="Casiglia E" first="Edoardo" last="Casiglia">Edoardo Casiglia</name></author><author><name sortKey="Jukema, J Wouter" sort="Jukema, J Wouter" uniqKey="Jukema J" first="J. Wouter" last="Jukema">J. Wouter Jukema</name></author><author><name sortKey="Simpson, Lara M" sort="Simpson, Lara M" uniqKey="Simpson L" first="Lara M." last="Simpson">Lara M. Simpson</name></author><author><name sortKey="Giampaoli, Simona" sort="Giampaoli, Simona" uniqKey="Giampaoli S" first="Simona" last="Giampaoli">Simona Giampaoli</name></author><author><name sortKey="Nordestgaard, Barge G" sort="Nordestgaard, Barge G" uniqKey="Nordestgaard B" first="Barge G." last="Nordestgaard">Barge G. Nordestgaard</name></author><author><name sortKey="Selmer, Randi" sort="Selmer, Randi" uniqKey="Selmer R" first="Randi" last="Selmer">Randi Selmer</name></author><author><name sortKey="Wennberg, Patrik" sort="Wennberg, Patrik" uniqKey="Wennberg P" first="Patrik" last="Wennberg">Patrik Wennberg</name></author><author><name sortKey="Kauhanen, Jussi" sort="Kauhanen, Jussi" uniqKey="Kauhanen J" first="Jussi" last="Kauhanen">Jussi Kauhanen</name></author><author><name sortKey="Salonen, Jukka T" sort="Salonen, Jukka T" uniqKey="Salonen J" first="Jukka T." last="Salonen">Jukka T. Salonen</name></author><author><name sortKey="Dankner, Rachel" sort="Dankner, Rachel" uniqKey="Dankner R" first="Rachel" last="Dankner">Rachel Dankner</name></author><author><name sortKey="Barrett Connor, Elizabeth" sort="Barrett Connor, Elizabeth" uniqKey="Barrett Connor E" first="Elizabeth" last="Barrett-Connor">Elizabeth Barrett-Connor</name></author><author><name sortKey="Kavousi, Maryam" sort="Kavousi, Maryam" uniqKey="Kavousi M" first="Maryam" last="Kavousi">Maryam Kavousi</name></author><author><name sortKey="Gudnason, Vilmundur" sort="Gudnason, Vilmundur" uniqKey="Gudnason V" first="Vilmundur" last="Gudnason">Vilmundur Gudnason</name></author><author><name sortKey="Evans, Denis" sort="Evans, Denis" uniqKey="Evans D" first="Denis" last="Evans">Denis Evans</name></author><author><name sortKey="Wallace, Robert B" sort="Wallace, Robert B" uniqKey="Wallace R" first="Robert B." last="Wallace">Robert B. Wallace</name></author><author><name sortKey="Cushman, Mary" sort="Cushman, Mary" uniqKey="Cushman M" first="Mary" last="Cushman">Mary Cushman</name></author></analytic><series><title level="j" type="main">JAMA, the journal of the American Medical Association</title><title level="j" type="abbreviated">JAMA j. Am. Med. Assoc.</title><idno type="ISSN">0098-7484</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">JAMA, the journal of the American Medical Association</title><title level="j" type="abbreviated">JAMA j. Am. Med. Assoc.</title><idno type="ISSN">0098-7484</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cardiovascular disease</term><term>Glycated hemoglobin</term><term>Hemoglobin A1c</term><term>Medicine</term><term>Prediction</term><term>Predictive factor</term><term>Quantitative analysis</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Hémoglobine glyquée</term><term>Hémoglobine A1c</term><term>Analyse quantitative</term><term>Prédiction</term><term>Facteur prédictif</term><term>Pathologie de l'appareil circulatoire</term><term>Médecine</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Analyse quantitative</term><term>Médecine</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">IMPORTANCE The value of measuring levels of glycated hemoglobin (HbA<sub>1c</sub>) for the prediction of first cardiovascular events is uncertain. OBJECTIVE To determine whether adding information on HbA<sub>1c</sub> values to conventional cardiovascular risk factors is associated with improvement in prediction of cardiovascular disease (CVD) risk. DESIGN. SETTING, AND PARTICIPANTS Analysis of individual-participant data available from 73 prospective studies involving 294 998 participants without a known history of diabetes mellitus or CVD at the baseline assessment. MAIN OUTCOMES AND MEASURES Measures of risk discrimination for CVD outcomes (eg, C-index) and reclassification (eg, net reclassification improvement) of participants across predicted 10-year risk categories of low (<5%), intermediate (5% to <7.5%), and high (≥7.5%) risk. RESULTS During a median follow-up of 9.9 (interquartile range, 7.6-13.2) years, 20 840 incident fatal and nonfatal CVD outcomes (13 237 coronary heart disease and 7603 stroke outcomes) were recorded. In analyses adjusted for several conventional cardiovascular risk factors, there was an approximately J-shaped association between HbA<sub>1c</sub> values and CVD risk. The association between HbA<sub>1c</sub> values and CVD risk changed only slightly after adjustment for total cholesterol and triglyceride concentrations or estimated glomerular filtration rate, but this association attenuated somewhat after adjustment for concentrations of high-density lipoprotein cholesterol and C-reactive protein. The C-index for a CVD risk prediction model containing conventional cardiovascular risk factors alone was 0.7434 (95% CI, 0.7350 to 0.7517). The addition of information on HbA<sub>1c</sub> was associated with a C-index change of 0.0018 (0.0003 to 0.0033) and a net reclassification improvement of 0.42 (-0.63 to 1.48) for the categories of predicted 10-year CVD risk. The improvement provided by HbA<sub>1c</sub> assessment in prediction of CVD risk was equal to or better than estimated improvements for measurement of fasting, random, or postload plasma glucose levels. CONCLUSIONS AND RELEVANCE In a study of individuals without known CVD or diabetes, additional assessment of HbA<sub>1c</sub> values in the context of CVD risk assessment provided little incremental benefit for prediction of CVD risk.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Autriche</li><li>Finlande</li><li>France</li><li>Japon</li><li>Norvège</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>Suède</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Angleterre de l'Est</li><li>Bade-Wurtemberg</li><li>District de Karlsruhe</li><li>East Middle Sweden</li><li>Grand Londres</li><li>Groningue (province)</li><li>Gueldre (province)</li><li>Hollande-Septentrionale</li><li>Massachusetts</li><li>Pennsylvanie</li><li>Svealand</li><li>Washington (État)</li><li>Écosse</li></region><settlement><li>Amsterdam</li><li>Cambridge</li><li>Groningue (ville)</li><li>Heidelberg</li><li>Londres</li><li>Pittsburgh</li><li>Seattle</li><li>Uppsala</li><li>Wageningue</li><li>Édimbourg</li></settlement><orgName><li>University College de Londres</li><li>Université d'Uppsala</li><li>Université d'Édimbourg</li><li>Université de Cambridge</li><li>Université de Groningue</li><li>Université de Londres</li><li>Université de Pittsburgh</li><li>Université de Wageningue</li><li>Université de Washington</li></orgName></list><tree><noCountry><name sortKey="Barrett Connor, Elizabeth" sort="Barrett Connor, Elizabeth" uniqKey="Barrett Connor E" first="Elizabeth" last="Barrett-Connor">Elizabeth Barrett-Connor</name><name sortKey="Bjorkelund, Cecilia" sort="Bjorkelund, Cecilia" uniqKey="Bjorkelund C" first="Cecilia" last="Björkelund">Cecilia Björkelund</name><name sortKey="Blazer, Dan G" sort="Blazer, Dan G" uniqKey="Blazer D" first="Dan G." last="Blazer">Dan G. Blazer</name><name sortKey="Casiglia, Edoardo" sort="Casiglia, Edoardo" uniqKey="Casiglia E" first="Edoardo" last="Casiglia">Edoardo Casiglia</name><name sortKey="Cushman, Mary" sort="Cushman, Mary" uniqKey="Cushman M" first="Mary" last="Cushman">Mary Cushman</name><name sortKey="Dankner, Rachel" sort="Dankner, Rachel" uniqKey="Dankner R" first="Rachel" last="Dankner">Rachel Dankner</name><name sortKey="Evans, Denis" sort="Evans, Denis" uniqKey="Evans D" first="Denis" last="Evans">Denis Evans</name><name sortKey="Ford, Ian" sort="Ford, Ian" uniqKey="Ford I" first="Ian" last="Ford">Ian Ford</name><name sortKey="Gallacher, John" sort="Gallacher, John" uniqKey="Gallacher J" first="John" last="Gallacher">John Gallacher</name><name sortKey="Giampaoli, Simona" sort="Giampaoli, Simona" uniqKey="Giampaoli S" first="Simona" last="Giampaoli">Simona Giampaoli</name><name sortKey="Goldbourt, Uri" sort="Goldbourt, Uri" uniqKey="Goldbourt U" first="Uri" last="Goldbourt">Uri Goldbourt</name><name sortKey="Gomez De Ia Camara, Agustin" sort="Gomez De Ia Camara, Agustin" uniqKey="Gomez De Ia Camara A" first="Agustin" last="Gomez-De-Ia-Camara">Agustin Gomez-De-Ia-Camara</name><name sortKey="Gudnason, Vilmundur" sort="Gudnason, Vilmundur" uniqKey="Gudnason V" first="Vilmundur" last="Gudnason">Vilmundur Gudnason</name><name sortKey="Ibanez, Alejandro Marin" sort="Ibanez, Alejandro Marin" uniqKey="Ibanez A" first="Alejandro Marín" last="Ibanez">Alejandro Marín Ibanez</name><name sortKey="Jukema, J Wouter" sort="Jukema, J Wouter" uniqKey="Jukema J" first="J. Wouter" last="Jukema">J. Wouter Jukema</name><name sortKey="Kauhanen, Jussi" sort="Kauhanen, Jussi" uniqKey="Kauhanen J" first="Jussi" last="Kauhanen">Jussi Kauhanen</name><name sortKey="Kavousi, Maryam" sort="Kavousi, Maryam" uniqKey="Kavousi M" first="Maryam" last="Kavousi">Maryam Kavousi</name><name sortKey="Nordestgaard, Barge G" sort="Nordestgaard, Barge G" uniqKey="Nordestgaard B" first="Barge G." last="Nordestgaard">Barge G. Nordestgaard</name><name sortKey="Onat, Altan" sort="Onat, Altan" uniqKey="Onat A" first="Altan" last="Onat">Altan Onat</name><name sortKey="Rosengren, Annika" sort="Rosengren, Annika" uniqKey="Rosengren A" first="Annika" last="Rosengren">Annika Rosengren</name><name sortKey="Salonen, Jukka T" sort="Salonen, Jukka T" uniqKey="Salonen J" first="Jukka T." last="Salonen">Jukka T. Salonen</name><name sortKey="Selmer, Randi" sort="Selmer, Randi" uniqKey="Selmer R" first="Randi" last="Selmer">Randi Selmer</name><name sortKey="Simons, Leon A" sort="Simons, Leon A" uniqKey="Simons L" first="Leon A." last="Simons">Leon A. Simons</name><name sortKey="Simpson, Lara M" sort="Simpson, Lara M" uniqKey="Simpson L" first="Lara M." last="Simpson">Lara M. Simpson</name><name sortKey="Sutherland, Susan E" sort="Sutherland, Susan E" uniqKey="Sutherland S" first="Susan E." last="Sutherland">Susan E. Sutherland</name><name sortKey="Wallace, Robert B" sort="Wallace, Robert B" uniqKey="Wallace R" first="Robert B." last="Wallace">Robert B. Wallace</name><name sortKey="Wassertheil Smoller, Sylvia" sort="Wassertheil Smoller, Sylvia" uniqKey="Wassertheil Smoller S" first="Sylvia" last="Wassertheil-Smoller">Sylvia Wassertheil-Smoller</name><name sortKey="Wennberg, Patrik" sort="Wennberg, Patrik" uniqKey="Wennberg P" first="Patrik" last="Wennberg">Patrik Wennberg</name></noCountry><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Di Angelantonio, Emanuele" sort="Di Angelantonio, Emanuele" uniqKey="Di Angelantonio E" first="Emanuele" last="Di Angelantonio">Emanuele Di Angelantonio</name></region><name sortKey="Brunner, Eric J" sort="Brunner, Eric J" uniqKey="Brunner E" first="Eric J." last="Brunner">Eric J. Brunner</name><name sortKey="Butterworth, Adam S" sort="Butterworth, Adam S" uniqKey="Butterworth A" first="Adam S." last="Butterworth">Adam S. Butterworth</name><name sortKey="Gao, Pei" sort="Gao, Pei" uniqKey="Gao P" first="Pei" last="Gao">Pei Gao</name><name sortKey="Kaptoge, Stephen" sort="Kaptoge, Stephen" uniqKey="Kaptoge S" first="Stephen" last="Kaptoge">Stephen Kaptoge</name><name sortKey="Khan, Hassan" sort="Khan, Hassan" uniqKey="Khan H" first="Hassan" last="Khan">Hassan Khan</name><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay-Tee" last="Khaw">Kay-Tee Khaw</name><name sortKey="Lawlor, Debbie A" sort="Lawlor, Debbie A" uniqKey="Lawlor D" first="Debbie A." last="Lawlor">Debbie A. Lawlor</name><name sortKey="Price, Jackie F" sort="Price, Jackie F" uniqKey="Price J" first="Jackie F." last="Price">Jackie F. Price</name><name sortKey="Sarwar, Nadeem" sort="Sarwar, Nadeem" uniqKey="Sarwar N" first="Nadeem" last="Sarwar">Nadeem Sarwar</name><name sortKey="Sreenivasa Rao Kondapally Seshasai" sort="Sreenivasa Rao Kondapally Seshasai" uniqKey="Sreenivasa Rao Kondapally Seshasai" last="Sreenivasa Rao Kondapally Seshasai">SREENIVASA RAO KONDAPALLY SESHASAI</name><name sortKey="Thompson, Alex" sort="Thompson, Alex" uniqKey="Thompson A" first="Alex" last="Thompson">Alex Thompson</name><name sortKey="Wald, Nicholas" sort="Wald, Nicholas" uniqKey="Wald N" first="Nicholas" last="Wald">Nicholas Wald</name><name sortKey="Whincup, Peter H" sort="Whincup, Peter H" uniqKey="Whincup P" first="Peter H." last="Whincup">Peter H. Whincup</name><name sortKey="Willeit, Peter" sort="Willeit, Peter" uniqKey="Willeit P" first="Peter" last="Willeit">Peter Willeit</name><name sortKey="Wormser, David" sort="Wormser, David" uniqKey="Wormser D" first="David" last="Wormser">David Wormser</name></country><country name="États-Unis"><region name="Massachusetts"><name sortKey="Ridker, Paul M" sort="Ridker, Paul M" uniqKey="Ridker P" first="Paul M." last="Ridker">Paul M. Ridker</name></region><name sortKey="Kuller, Lewis H" sort="Kuller, Lewis H" uniqKey="Kuller L" first="Lewis H." last="Kuller">Lewis H. Kuller</name><name sortKey="Psaty, Bruce M" sort="Psaty, Bruce M" uniqKey="Psaty B" first="Bruce M." last="Psaty">Bruce M. Psaty</name><name sortKey="Psaty, Bruce M" sort="Psaty, Bruce M" uniqKey="Psaty B" first="Bruce M." last="Psaty">Bruce M. Psaty</name></country><country name="Australie"><noRegion><name sortKey="Barr, Elizabeth L M" sort="Barr, Elizabeth L M" uniqKey="Barr E" first="Elizabeth L. M." last="Barr">Elizabeth L. M. Barr</name></noRegion><name sortKey="Knuiman, Matthew W" sort="Knuiman, Matthew W" uniqKey="Knuiman M" first="Matthew W." last="Knuiman">Matthew W. Knuiman</name></country><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name></region></country><country name="France"><noRegion><name sortKey="Balkau, Beverley" sort="Balkau, Beverley" uniqKey="Balkau B" first="Beverley" last="Balkau">Beverley Balkau</name></noRegion><name sortKey="Balkau, Beverley" sort="Balkau, Beverley" uniqKey="Balkau B" first="Beverley" last="Balkau">Beverley Balkau</name></country><country name="Pays-Bas"><region name="Hollande-Septentrionale"><name sortKey="Dekker, Jacqueline M" sort="Dekker, Jacqueline M" uniqKey="Dekker J" first="Jacqueline M." last="Dekker">Jacqueline M. Dekker</name></region><name sortKey="Bakker, Stephan J L" sort="Bakker, Stephan J L" uniqKey="Bakker S" first="Stephan J. L." last="Bakker">Stephan J. L. Bakker</name><name sortKey="Feskens, Edith J M" sort="Feskens, Edith J M" uniqKey="Feskens E" first="Edith J. M." last="Feskens">Edith J. M. Feskens</name><name sortKey="Verschuren, W M M" sort="Verschuren, W M M" uniqKey="Verschuren W" first="W. M. M." last="Verschuren">W. M. M. Verschuren</name></country><country name="Japon"><noRegion><name sortKey="Daimon, Makoto" sort="Daimon, Makoto" uniqKey="Daimon M" first="Makoto" last="Daimon">Makoto Daimon</name></noRegion></country><country name="Autriche"><noRegion><name sortKey="Willeit, Johann" sort="Willeit, Johann" uniqKey="Willeit J" first="Johann" last="Willeit">Johann Willeit</name></noRegion></country><country name="Norvège"><noRegion><name sortKey="Nj Lstad, Inger" sort="Nj Lstad, Inger" uniqKey="Nj Lstad I" first="Inger" last="Nj Lstad">Inger Nj Lstad</name></noRegion></country><country name="Finlande"><noRegion><name sortKey="Nissinen, Aulikki" sort="Nissinen, Aulikki" uniqKey="Nissinen A" first="Aulikki" last="Nissinen">Aulikki Nissinen</name></noRegion></country><country name="Suède"><region name="Svealand"><name sortKey="Sundstrom, Johan" sort="Sundstrom, Johan" uniqKey="Sundstrom J" first="Johan" last="Sundström">Johan Sundström</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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